[en] This paper presents a brief review of the irradiation creep mechanism, analyses of the effect on the performance and behaviour of fusion in-vessel components, and discusses procedures for the estimation of in-service time (or lifetime) of components under combined creep-fatigue. The irradiation creep models and proposed theories are examined and analysed to produce a creep law relevant to fusion conditions. The necessary material data, constitutive equations and other parameters needed for estimation of in-service time from the combination of creep and fatigue damage are identified. Wherever possible, design curves are proposed for stress and strain. Time dependent non-linear elastoplastic example calculations are performed, for a typical first wall structure under power plant loading conditions, assuming austenitic and martensitic steel as structural materials, including material irradiation creep. The results of calculations for the stress and strain history of the first wall are used together with the proposed cumulative damage expressions derived in this study to estimate the in-service time, including the effects of stress relaxation due to creep, reduction of ductility (or fracture strain) and helium-to-displacement-damage ratio. The calculations give a displacement damage of ∼70 dpa for the 316 austenitic steel and ∼110-130 dpa for the martensitic steel. Provided there are no power transients, for a design strain of 0.5%, the in-service time is estimated to be ∼3 years for the 316 steel case (at 2.2 MW/m² wall load) and the high wall loading martensitic steel (5.0 MW/m² case), and ∼5.3 years for the martensitic steel at lower wall load (2.2 MW/m² case). The difficulty in defending these results lies in the uncertainty arising from the limited database and experience of the material properties, especially the creep constitutive law, when exposed to fusion environments