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AbstractAbstract
[en] Aim: 117mSn has a half-life of 14.0 days, decays to stable 117Sn emitting a γ-ray of 159 keV, that can be used for obtaining in vivo images. It main use is in therapy, as a bone cancer therapeutical agent, due to the conversion electrons of 126.8 and 151.6 keV. The nuclear reactions that lead to the production of this isotope are: 117Sn (p, n) 117Sb→ 117mSn, 118Sn (p, 2n) 117Sb → 117mSn and 119Sn (p, 3n) 117Sb → 117mSn. The objective of this work is to describe a production method of high specific activity 117mSn. Materials and Methods: 1. Irradiation of natural tin in the CV-28 Cyclotron at IPEN-CNEN/SP. 2. Chemical separation of tin - antimony by an ion exchange technique. 3. Quality control of 117mSn: chemical, radiochemical and radionuclidic impurities. Results: 1. The thick target yield for the production of 117mSn was 0.784 MBq/□Ah. 2. The target was dissolved into concentrated HCl, hydrazine was then added for oxidizing and the solution taken to dryness. The solid was dissolved with concentrated HCl and the chemical separation was processed in an anion resin Dowex AG1-X8 (50 - 100 mesh). 3. The chemical levels of tin and antimony were 3 ppm and less than 2 ppm, respectively. Nearly 97% of 117mSn was in the form of Sn+4. The radionuclidic impurity level of 113Sn and 119mSn can be strongly reduced if the first chemical separation is performed 2 hours after the end of the bombardment and the decay time of 117Sb is reduced to 19 hours. Conclusions: A reliable production method of 117mSn was developed through the irradiation of tin target
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Secondary Subject
Source
8. Congress of the World Federation of Nuclear Medicine and Biology; Santiago (Chile); 29 Sep - 2 Oct 2002
Record Type
Journal Article
Literature Type
Conference
Journal
World Journal of Nuclear Medicine; ISSN 1450-1147;
; v. 1(suppl.2); p. 314-315

Country of publication
BEAMS, BETA DECAY RADIOISOTOPES, CONTROL, DAYS LIVING RADIOISOTOPES, DRUGS, ELECTRON CAPTURE RADIOISOTOPES, EVEN-ODD NUCLEI, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, MINUTES LIVING RADIOISOTOPES, NUCLEI, NUCLEON BEAMS, PARTICLE BEAMS, RADIOACTIVE MATERIALS, RADIOISOTOPES, STABLE ISOTOPES, TIN ISOTOPES
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