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[en] The regeneration processes were investigated in the rat thymus after heavy dose irradiation (6 and 8 Gy). The weight of thymus was gradually recovered to normal level in 6 Gy irradiated thymus, however it recovered only up to 65% of normal level in 8 Gy irradiated thymus. The ED2 positive macrophages were increased on day 3, and then gradually decreased to normal level in 6 Gy irradiated thymus. Inflammatory cytokines (IL-1β, IFN-γ and TNF-α) mRNA expressions were gradually recovered from day 7, however IL-6 mRNA was expressed transiently on day 7 after 8 Gy irradiation. These observations suggest that regeneration processes of irradiated thymus may be intimately regulated by cytokine networks. (author)
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Tanaka, Kimio; Takabatake, Takashi; Fujikawa, Katsuyoshi; Matsumoto, Tsuneya; Sato, Fumiaki (Inst. for Environmental Sciences, Rokkasho, Aomori (Japan)) (eds.); 367 p; ISBN 4-9980604-5-7; 
; 2003; p. 176-181; International symposium on biological effects of low dose radiation: Molecular mechanisms for radiation-induced cellular response and cancer development; Rokkasho, Aomori (Japan); 9-11 Oct 2002; 12 refs., 4 figs.
; 2003; p. 176-181; International symposium on biological effects of low dose radiation: Molecular mechanisms for radiation-induced cellular response and cancer development; Rokkasho, Aomori (Japan); 9-11 Oct 2002; 12 refs., 4 figs.