[en] The risk-informed reevaluation of 10 CFR 50.46 (along with Appendix K and GDC 35), the emergency core cooling system (ECCS) requirements, utilizes loss of coolant accident (LOCA) initiating event frequencies to evaluate the technical basis for potential related rule changes. A longer-term effort is considering redefining the maximum design basis pipe break size for sizing the ECCS system. In the past few years, the U.S. Nuclear Regulatory Commission (NRC) has utilized NUREG/CR-5750 pipe-break LOCA estimated for initiating event frequencies. However, several failure mechanisms have recently emerged at plants which have not been evident within the service period covered by the NUREG/CR-5750 estimates. The concern is that these and other potential aging-related mechanisms may not be adequately represented within the NUREG/CR-5750 LOCA estimates. Additionally, LOCAs can occur from failure of active components (e.g. safety relief valves, reactor coolant pump seals, etc.) and other non-pipe break passive failures (e.g. steam generator tubes). The LOCA contributions from these additional sources must also be considered in deciding the design basis break size. The LOCA estimates must also attempt to capture expected future changes in the LOCA frequencies so that the estimates are pertinent up through the end of the license renewal period. (orig.)