[en] A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[²¹¹ At]astatobenzoate and N-succinimidyl 3-[¹³¹I]iodobenzoate. Over the 48-h observation period, the distribution of ²¹¹At- and ¹³¹I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered ²¹¹At-labeled chimeric 81C6 using a quality factor of 5 for α-emissions