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AbstractAbstract
[en] The binding of the three dopamine transporter radioligands ([125I]β-CIT, [125I]β-CIT-FE, and [125I]β-CIT-FP) was studied using whole-hemisphere autoradiography on postmortem human brains. The autoradiograms revealed an intense and homogeneous labeling of the nucleus caudatus and putamen but also to varying extent to serotonergic and noradrenergic transporters of neocortex and thalamus. The order of specificity estimated (striatum over neocortex ratios) was β-CIT-FP > β-CIT-FE >> β-CIT, suggesting that β-CIT-FE and β-CIT-FP should be preferred for in vivo studies of the dopamine transporter in the human brain
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Source
S0969805197000814; Copyright (c) 1997 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
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AMINES, ANIMALS, AROMATICS, AUTONOMIC NERVOUS SYSTEM AGENTS, BETA DECAY RADIOISOTOPES, BODY, BRAIN, CARDIOTONICS, CARDIOVASCULAR AGENTS, CENTRAL NERVOUS SYSTEM, DAYS LIVING RADIOISOTOPES, DRUGS, ELECTRON CAPTURE RADIOISOTOPES, HYDROXY COMPOUNDS, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, IODINE ISOTOPES, ISOTOPES, MAMMALS, NERVOUS SYSTEM, NEUROREGULATORS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANS, PHENOLS, POLYPHENOLS, PRIMATES, RADIOISOTOPES, SYMPATHOMIMETICS, VERTEBRATES
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