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[en] Preparation And Stability Studies Of Renium-186-EDTMP. 99mTc phosphonates are widely used as a bone imaging agent and their rhenium analog 186Re phosphonates are now well established as a therapeutic radiopharmaceuticals for palliation of pain due to bone metastases. As part of our development program on rhenium radiopharmaceuticals at the Center for Development of Radioisotopes and Radiopharmaceuticals-BATAN, labeling of EDTMP (ethylenediamine-N,N,N',N'-tetrakis (methylenephosphonic acid) with 186Re was carried out and its high radiochemical purity was quite stable over 8 days at room temperature. Rhenium-186 was prepared by irradiation of high enriched 185Re (97%) metal at a neutron flux of 3,7 x 10.13 n/cm12/s for five days and processed after a cooling period of four days. A complex of 186Re-EDTMP with radiochemical purity of 90% could be prepared by varying the reaction condition, such as pH and amount of EDTMP and Sn2+. A complex with addition of ascorbic acid retains its high radiochemical purity up to 4 days when stored at room temperature
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Sofyan, Rochestri; Rahardjo, Henky P.; Nurdin, Martias; Umar, Efrizon; Margono; Tanudjojo, Nurhayati; Kukuh, Ratnawati; Nurlaila, Z.; Faruq, Muhammad; Sambodo, Guntur Daru (National Nuclear Energy Agency, Bandung (Indonesia)) (eds.); Center for Research and Development of Nuclear Techniques, National Nuclear Energy Agency, Bandung (Indonesia); 651 p; ISSN 1410-1769; 
; Sep 2000; p. 272-280; Conference on the Role of Nuclear Science and Technology on Empowering National Potential; Prosiding Seminar Sains dan Teknologi Nuklir Dalam Pemberdayaan Potensi Nasional; Bandung (Indonesia); 11-12 Jul 2000; Available from Center for Development of Informatics and Computation Technology, National Nuclear Energy Agency, Puspiptek Area, Fax. 62-21-7560923, PO BOX 4274, Jakarta (ID); 12 refs.; tabs.; 6 figs.
; Sep 2000; p. 272-280; Conference on the Role of Nuclear Science and Technology on Empowering National Potential; Prosiding Seminar Sains dan Teknologi Nuklir Dalam Pemberdayaan Potensi Nasional; Bandung (Indonesia); 11-12 Jul 2000; Available from Center for Development of Informatics and Computation Technology, National Nuclear Energy Agency, Puspiptek Area, Fax. 62-21-7560923, PO BOX 4274, Jakarta (ID); 12 refs.; tabs.; 6 figs.