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AbstractAbstract
[en] Purpose/Objective: Over the last decade, there has been increasing interest in several radiobiological parameters as predictors of tumor response to radiation. Each parameter was evaluated alone. The clinical outcome was correlated and the results were mixed. In this study, we evaluated several parameters in the same tumor as predictors of response to fractionated irradiation of nine human xenografts. Methods and Materials: The fractionated TCD50 (the dose of radiation which controls 50% of the tumors) using 30 fractions in 15 days of nine human tumor xenografts were determined. The tumors were implanted in the hindleg of nude mice. The parameters pO2, IFP (interstitial fluid pressure), Tpot, SF2, Do, GSH, TCD50 single dose in oxic and hypoxic conditions, the rate of metastasis in SCID mice and the TD50 (the number of cells which induced tumors in 50% of the animals) were evaluated. The hypoxic fraction was also calculated. Results: Five glioblastoma, two squamous, one sarcoma and one colon cancer xenografts were studied. When each parameter was considered alone, none of the parameters investigated correlated with the fractionated TCD50. No correlation was found between the hypoxic fraction calculated from the TCD50 under oxic and hypoxic conditions and the pO2 values for the same tumor. None of the parameters evaluated predicted the metastatic potential of these xenografts. Conclusion: These data suggest that one parameter could not predict the fractionated TCD50 and that the response of human tumor xenografts to irradiation is multifactorial
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Copyright (c) 1995 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016;
; CODEN IOBPD3; v. 32(971); p. 250

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