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AbstractAbstract
[en] This course will address the primary and adjuvant role of ionizing radiation in the management of nasopharyngeal, nasal cavity and paranasal sinus cancers. Nasopharynx: Primary irradiation of nasopharyngeal carcinoma is technically challenging because of its proximity to the base of skull and central nervous system. Careful planning and an in-depth understanding of skull-base anatomy, patterns of local-regional spread and radiation tolerance of brain, spinal cord, optic nerves and retina are required. The theoretical advantages of three-dimensional planning and delivery of dose with modulated-intensity x-ray beams and protons, though promising, remain unsubstantiated. What has been established is that non-keratinizing WHO 2 and 3 cancers of the nasopharynx are more radiocurable than keratinizing ones and that chemotherapy in addition to radiation, though toxic, improves disease-free survival. The limited role of surgery and retreatment by external beam and endocavity brachytherapy will be discussed. Nasal Cavity: Radiation alone is preferentially used for cancers within the vestibule of the external nose because of its cosmetic importance and the impossible task of reconstructing it after rhinectomy. Cancers of the nasal cavity often behave like paranasal sinus cancers and require resection with adjuvant pre- or postoperative irradiation. Techniques of interrstitial implantation and external irradiation of the nose will be described. Paranasal Sinus: Radiation is used before or after surgery for resectable cancers of the paranasal sinus or as a single modality for unresectable ones. Those which involve the maxillary suprastructure are irradiated with ethmoido-maxillary technique while those of the infrastructure, are irradiated with a classic wedge-pair technique. Dose escalation is limited by the tolerance of the retina, optic nerves and brain
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Source
S0360301697804944; Copyright (c) 1997 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016;
; CODEN IOBPD3; v. 39(2,suppl.1); p. 113

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