Filters
Results 1 - 1 of 1
Results 1 - 1 of 1.
Search took: 0.023 seconds
AbstractAbstract
[en] Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)
Original Title
Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero
Primary Subject
Source
Sep 2002; 80 p; 53 refs., 18 figs., 11 tabs.; Dissertacao (M.Sc.)
Record Type
Miscellaneous
Literature Type
Thesis/Dissertation; Numerical Data
Report Number
Country of publication
ANIMAL CELLS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BLOOD, BLOOD CELLS, BODY FLUIDS, COBALT ISOTOPES, CONNECTIVE TISSUE CELLS, DATA, DISEASES, DOSES, INFORMATION, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LEUKOCYTES, MATERIALS, MEDICINE, MINUTES LIVING RADIOISOTOPES, MUTATIONS, NEOPLASMS, NUCLEAR MEDICINE, NUCLEI, NUMERICAL DATA, ODD-ODD NUCLEI, RADIATIONS, RADIOISOTOPES, RADIOLOGY, SOMATIC CELLS, THERAPY, YEARS LIVING RADIOISOTOPES
LanguageLanguage
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue