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AbstractAbstract
[en] The present work reports the obtention of macro aggregates of hydroxides of Dysprosium-166/Holmium-166 (166 Dy/166 Ho-MH), as a generator system in vivo to be used in the treatment of arthritis rheumatoid. The 166 Dy was obtained by neutron irradiation of 166 DyO3 (enriched to 98.45%) by 20 h in the TRIGA Mark III Reactor and 50 h of decay, to the oxide of 166 Dy/166 Ho formed, it was added HCl 0.12 N to obtain a final volume of 3.5 ml of solution of 166 Dy/166 Ho chloride. The solution of 166DyCl3 solution was obtained with an activity of 3.502 mCi (129 MBq), appropriate for the preparation of the radiopharmaceutical 166 Dy/166 Ho-MH. The separation of the 166 Dy from the 166 Ho, was carried out by chromatography in an cation exchange column, gaining an appropriate separation, obtaining a 166 Dy with a radionuclide purity greater than 90%. The 166 Dy/166 Ho-MH were prepared by addition to the solution of 166 DyCI3 NaOH 0.5 N low ultrasonic bath with later centrifugation, decanted and resuspension in saline solution, obtaining a radiopharmaceutical with a generator system 166 Dy/ 166 Ho with particles of size average of 3 μm, in form of 166 Dy / 166 Ho-MH. Under these conditions, it was obtained a radiochemical yield greater than 99%. The microscopic analysis and of filtration showed that the formulation doesn't present particles smaller than to 1 μm, neither greater to 50 μm, which will allow, the quick phagocytosis for the synoviocytes of the synovial membrane, and by consequence, an homogeneous distribution of the radiation dose could exist. The sedimentation velocity for the formulated suspension is of 0.04 cm/min that it will allow the administration of homogeneous activities of the radiopharmaceutical, to the no deposit in the injection devices. The studies of stability in vitro indicate us that inside the articulation, the particles won't probably reduce its size neither their radiochemical purity, for that the flight extra articular will be smaller that 1% besides that the 166 Dy /166 Ho-MH will stay stable for more of 8 days. By means of the preparation process used in the elaboration of 3 lots, it was obtained to the radiopharmaceutical with a high radiochemical purity, finding uniformity among them. (Author)
Original Title
Preparacion de 166 Dy/166 Ho-Macro agregados como un sistema de generador In vivo para el tratamiento de artropatias
Primary Subject
Source
2003; 95 p; Thesis (Pharmaceutical Biologist Chemist)
Record Type
Miscellaneous
Literature Type
Thesis/Dissertation
Report Number
Country of publication
BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CHLORIDES, CHLORINE COMPOUNDS, DATA, DAYS LIVING RADIOISOTOPES, DRUGS, DYSPROSIUM COMPOUNDS, DYSPROSIUM ISOTOPES, ENRICHED URANIUM REACTORS, EVEN-EVEN NUCLEI, HALIDES, HALOGEN COMPOUNDS, HOLMIUM ISOTOPES, HOMOGENEOUS REACTORS, HYDRIDE MODERATED REACTORS, INFORMATION, INTERMEDIATE MASS NUCLEI, IRRADIATION REACTORS, ISOTOPE PRODUCTION REACTORS, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, NUCLEI, NUMERICAL DATA, ODD-ODD NUCLEI, RADIOACTIVE MATERIALS, RADIOISOTOPES, RARE EARTH COMPOUNDS, RARE EARTH NUCLEI, REACTORS, RESEARCH AND TEST REACTORS, SIZE, SOLID HOMOGENEOUS REACTORS, THERMAL REACTORS, TRIGA TYPE REACTORS, WATER COOLED REACTORS, WATER MODERATED REACTORS, YEARS LIVING RADIOISOTOPES
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