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Palomares R, P.; Hernandez B, C.A.; Contreras N, G.; Garcia P, M.L.; Pantoja H, I.E.; Ferro F, G., E-mail: patodish@hotmail.com
Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de Mexico (Mexico); Comision Nacional de Seguridad Nuclear y Salvaguardias, Mexico D.F. (Mexico); Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Comision Federal de Electricidad, Gerencia de Centrales Nucleoelectricas, Mexico D.F. (Mexico)2004
Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de Mexico (Mexico); Comision Nacional de Seguridad Nuclear y Salvaguardias, Mexico D.F. (Mexico); Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Comision Federal de Electricidad, Gerencia de Centrales Nucleoelectricas, Mexico D.F. (Mexico)2004
AbstractAbstract
[en] The 99m Tc-UBI 29-41 are a labelled fragment of the antimicrobial human peptide Ubiquicidine proposed as a new radiopharmaceutical able to differentiate an infectious process of an inflammatory one through the gamma graphic image. It has been demonstrated that the 99m Tc-UBI 29-41 unite to bacteria in vitro and that accumulates in infection sites in human with minimum captivation in inflammation sites. In this work the development of a pharmaceutical lyophilized formulation is presented for the instantaneous marked one of the UBI 29-41 with 99m Tc. The selection of the components of the formulation settled down by means of the employment of an experimental design of 3 factors with mixed levels, evaluating the effect of the diluent type, concentration of tinny chloride and the reaction volume. The obtained formulations showed to be stable until for 6 months, being obtained complexes of the radiolabelled peptide with radiochemical purity > 95 % in sterile form and apirogen. The developed pharmaceutical form, will facilitate the routinary use of this new radiopharmaceutical in the diverse hospital departments of nuclear medicine. (Author)
Original Title
Desarrollo de una formulacion liofilizada para la obtencion del peptido antimicrobiano Ubiquicidina marcado con Tc-99m
Primary Subject
Source
2004; 7 p; 15. Annual Congress of the SNM; Cancun (Mexico); 11-14 Jul 2004; 22. Annual Meeting of the SMSR; Cancun (Mexico); 11-14 Jul 2004; International Joint Meeting Cancun 2004; Cancun (Mexico); 11-14 Jul 2004; International Conjunct Congress Cancun 2004; Cancun (Mexico); 11-14 Jul 2004; 2004 LAS/ANS Symposium; Cancun (Mexico); 11-14 Jul 2004
Record Type
Miscellaneous
Literature Type
Conference
Report Number
Country of publication
ALBUMINS, AMINO ACIDS, ANTIMICROBIAL AGENTS, BLOOD SERUM, HYDROCHLORIC ACID, IN VITRO, KIDNEYS, LABELLED COMPOUNDS, LIQUID COLUMN CHROMATOGRAPHY, LYOPHILIZATION, NAI DETECTORS, PEPTIDES, RADIATION DOSES, SODIUM CHLORIDES, SOLID SCINTILLATION DETECTORS, TECHNETIUM 99, THALLIUM, THIN-LAYER CHROMATOGRAPHY
ALKALI METAL COMPOUNDS, ANTI-INFECTIVE AGENTS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BLOOD, BLOOD PLASMA, BODY, BODY FLUIDS, CARBOXYLIC ACIDS, CHLORIDES, CHLORINE COMPOUNDS, CHROMATOGRAPHY, DOSES, DRUGS, ELEMENTS, HALIDES, HALOGEN COMPOUNDS, HOURS LIVING RADIOISOTOPES, HYDROGEN COMPOUNDS, INORGANIC ACIDS, INORGANIC COMPOUNDS, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MATERIALS, MEASURING INSTRUMENTS, METALS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANS, PROTEINS, RADIATION DETECTORS, RADIOISOTOPES, SCINTILLATION COUNTERS, SEPARATION PROCESSES, SODIUM COMPOUNDS, SOLID SCINTILLATION DETECTORS, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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