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AbstractAbstract
[en] Toxicokinetics from earlier studies suggested that there Is high ferrocene hydroxylase activity in nasal tissue. We developed an assay using 59Fe-labeled ferrocene to confirm that nasal tissue, in particular olfactory tissue, has ferrocene hydroxylase activity exceeding that of liver by about a factor of ten. Because metabolism of ferrocene potentially leads to iron-catalyzed peroxidation, it was predicted that the olfactory tissue would be especially sensitive to toxic effects from inhaled ferrocene. This was confirmed in an independent study. (author)
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Source
Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.); Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States). Funding organisation: Office of Health and Environmental Research, U.S. Department of Energy (United States); 659 p; Dec 1988; p. 123-125; 2 refs, 1 fig., 1 tab
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Report
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ANIMALS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, CELL CONSTITUENTS, COMPLEXES, DAYS LIVING RADIOISOTOPES, DIENES, DIGESTIVE SYSTEM, ELEMENTS, ENZYMES, EVEN-ODD NUCLEI, GLANDS, HYDROCARBONS, INTERMEDIATE MASS NUCLEI, IRON COMPLEXES, IRON ISOTOPES, ISOTOPES, MAMMALS, METALS, NUCLEI, ORGANIC COMPOUNDS, ORGANS, OXIDOREDUCTASES, POLYENES, PROTEINS, RADIOISOTOPES, RIBOSOMES, RODENTS, TRANSITION ELEMENT COMPLEXES, TRANSITION ELEMENTS, VERTEBRATES
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