[en] CSN is responsible for the licensing and inspection of the radioactive facilities. In Spain several cyclotrons have been installed for production of positron emitting radionuclides for use in diagnosis and nuclear medicine investigation. Currently there are 6 cyclotrons, the first one began to operate in Madrid in 1996 and the last two in Sevilla and Madrid in March, 2001. Two of them are an auto shielded cyclotron. All accelerate negative ion (H -), Only one, in addition, accelerates deuteron (d). The acceleration energies range between 9 to 18 MeV, current intensity varies from 50 to 100 μA. Maximum activities of radioisotope, focussing exclusively on the 1^8F, being the one that they mainly produce, fluctuate between 1.4 and 5 Ci (52 -185 GBq) at the end of bombardment. These facilities of positron emitting isotope production consist basically of a cyclotron vault in which the bombardment of the targets takes place, a control room where the machine operation is controlled, a technical room, a hot laboratory where the chemical synthesis of the radiopharmaceuticals, 18 F-Fluordeoxiglucose (1^8FDG) and 13 N- Amonia takes place and finally a room for pharmaceutical quality control. The radiological hazards associated to this type of facilities are related to the external radiation and contamination. Main external radiation exposure only occurs during the bombardment of the target by the accelerated particles; this interaction produces prompt and secondary gamma, X rays and neutron radiation. Additionally, residual radioactivity induced by activation of the materials of the cyclotron exists, this should be taken into account mostly during the operations of maintenance, although in the Spanish cyclotrons, of negative ion beams, the residual radioactivity is lower compared to the positive ion beam ones