[en] A major issue to secure the development of nuclear energy in future is the radioactive waste minimization, both inside the fuel cycle and in a deep geological storage. The aim of this paper is to establish the physical principles which provide an inherent minimization of the radioactive wastes. A new concept is introduced to characterize the radiotoxicity associated to various nuclei families in equilibrium state. The analysis shows the potential of evolutionary nuclear systems, mostly based on known technologies and the potential of more futuristic systems, like accelerator-driven systems and Th-fuel cycle. Several groups of the toxicity sources are object of the studies: Actinides as a part of the nuclear fuel which is remaining unusable after irradiation in nuclear power plants; long-lived fission products as the inevitable result of nuclear energy production; Lanthanides as an important part of fission products which separation from Actinides is technologically difficult because of similar chemical properties