[en] 2005 was a year with significant improvements on the improvements on the linear accelerators but with repeated problems with the tandem. The linacs were set in operational status: the PIAVE injector was completely commissioned, while the problems with the cryogenic plant, arisen in 2004 in ALPI, were solved. On the other hand, the overall number of beam-on-target hours in 2005 was around one half of the LNL average of the last years. This was mainly due to the onset of a number of problems on the electrostatic machine. These were partly recovered at the end of the year, allowing quite regular operation to start again in 2006, though at a lower terminal voltage (¹3 instead of 15MV). Since July 2005, the superconducting linac was made again operational, allowing a couple of PIAVE-ALPI beam tests to be carried out successfully: they were conducted in July and in November-December, with both 16O and 22Ne beams. Moreover, the new distribution system of the cryogenic fluids was shown to work very satisfactorily, allowing the low-beta branch of ALPI (crucial for heavier nuclear species) to be cooled efficiently for the first time together with the rest of the linac. The first beam operation of low-beta section was done during the PIAVE beam tests of November-December. Within the activities related with the SPES project, it is worthwhile mentioning the installation of the TRIPS ion source at LNL, which can produce up to 60 mA of protons at 80 keV; the test will start within 2006. An intense activity has started on a new phase of the project, namely the development of the 238U single stage target, in synergy with interdisciplinary groups of Padua University and a strong collaboration with ORNL. Two different prototypes of the high power (150 kW) beryllium neutron production targets have been constructed and successfully tested, in collaboration with the Efremov Institute of Saint Petersburg. The high power neutron converter (200 kW) has been designed in collaboration with the Budker Institute of Nuclear Physics of Novosibirsk.The wide spectrum of the interdisciplinary research activities has been pursued and the major efforts have been focused on: radionuclide biodistribution studies for nuclear medicine and radiotherapy applications; radiobiology investigations also with the single-ion single-cell microbeam; PIXE and micro-PIXE analyses manly in the fields of environmental, hearth and archaeological sciences; studies or radiation induced failures on microelectronics devices; magneto-optical trapping; microdosimetry with Tissue Equivalent Proportional Counter and silicon detectors also in view of applications to Boron Neutron Capture Therapy. The gravitational wave detector Auriga has been taking data regularly all over the year with an efficiency of more than 96%. Data have been exchanged with the other collaborations working on the same subject. The R and D program for the new cryogenic massive detector DUAL is progressing. New data from the PVLAS experiment are maintaining very high the interest on the results of this experiment. Finally the Laboratory has given strong support to the CNAO activity for the construction of an ion-beams facility for the cancer therapy and to the preliminary studies of the Neutral Beam Injector prototype of the ITER project for the nuclear fusion