[en] This study evaluates the decorporation efficacy of a pulmonary administration of a new Ca-DTPA (diethylene-triamine-pentaacetic acid) dry powder (18 μmol kg^-1 of body mass) after pulmonary contamination of rats with different Pu compounds. After inhalation of PuO₂, a delayed intratracheal administration of DTPA cannot reduce significantly the retention of Pu in the lungs but limits its transfer in liver and skeleton. After pulmonary contamination by Pu nitrate, early insufflation of the DTPA powder appears twice as more efficient than an i.v injection of DTPA (30 μmol kg^-1) to reduce Pu retention in the lungs and is as effective as i.v. injection to limit the extra-pulmonary deposit. In contrast, a delayed administration of DTPA cannot reduce the lung or extra-pulmonary retention. In conclusion, the improvement of aerodynamic properties of DTPA powder leads to an increase of DTPA amount deposited in the lungs and enhances the body decorporation. (authors)