[en] Objective: To investigate the value of chest CT and detection of serum CYFRA21-1, NSE in diagnosis of pulmonary carcinoma. Methods: Chest CT were performed and serum levels of CYFRA21-1 and NSE were measured with RIA in 60 patients with pulmonary nodules, the sensitivity, specificity and accuracy of two methods for diagnosis of cancer were compared. Results The sensitivity, specificity and accuracy of the chest CT were 91.3%, 71.4% and 86.7% respectively, and with detection of serum CYFRA21-1 and NSE were 71.7%, 85.7% and 75.0%. Chest CT had higher sensitivity but lower specificity,and the reverse was true with detection of serum CYFRA21-1 and NSE. Conclusion: Both of chest CT and detection of serum CYFRA21-1 and NSE are important methods in diagnosis of pulmonary carcinoma and they are complementary to each other. (authors)