[en] Objective: To explore the mechanisms of preferential distribution of transplanted dermal muhipotent stem cells (dMSCs) to surface of wound in rats with combined radiation and wound injury (CRWI). Methods: The expression of stromal-dereived factor-1 (SDF-1) in wounds of rats and the expression of CXCR4 (the only known receptor of SDF-1) in dMSCs were examined using RT-PCR and immunohistochemistry. The chemotactic effect of SDF-1 on dMSCs was evaluated in Transwell culture system. Results: The expression of SDF-1 in wound of CRWI rats was upregulated significantly compared with the normal rats'skin, dMSCs expressed CXCR4. SDF-1 had a strong chemotactic effect on dMSCs; the chemotactic effect of wound extracts from CRWI rats was significantly reduced (P<0.05) when neutralized antibody to SDF-1 was added. Conclusion: The upregulated expression of SDF-1 played an important role in the preferential distribution of transplanted dMSCs to wound in rats with CRWI. (authors)