[en] Creation of synthetic cargo-container radiographs that possess attributes of their empirical counterparts requires accurate models of the imaging system response. Synthetic radiographs serve as surrogate data in studies aimed at determining system effectiveness for detecting target objects when it is impractical to collect a large set of empirical radiographs. In the case where a detailed understanding of the detector system is available, an accurate detector model can be derived from first principles. In the absence of this detail, it is necessary to derive empirical models of the imaging-system response from radiographs of well-characterized objects. Such a case is the topic of this work, where we demonstrate the development of an empirical model of a gamma-ray radiography system with the intent of creating a detector-response model that translates uncollided photon transport calculations into realistic synthetic radiographs. The detector-response model is calibrated to field measurements of well-characterized objects thus incorporating properties such as system sensitivity, spatial resolution, contrast, and noise