Filters
Results 1 - 1 of 1
Results 1 - 1 of 1.
Search took: 0.017 seconds
Saraswathy, P.; Dey, A.C.; Sarkar, S.K.; Kothalkar, C.; Naskar, P.; Arjun, G.; Arora, S.S.; Kohli, A.K.; Meera, V.; Venugopal, V.; Ramamoorthy, N.
2007 international meeting on Reduced Enrichment for Research and Test Reactors (RERTR). Abstracts and available papers presented at the meeting2008
2007 international meeting on Reduced Enrichment for Research and Test Reactors (RERTR). Abstracts and available papers presented at the meeting2008
AbstractAbstract
[en] The Indian pursuit of gel generator technology for 99mTc was driven mainly by three considerations, namely, (i) well-established and ease of reliable production of (n, gamma)-based 99Mo in several tens of GBq quantities in the research reactors in Trombay/Mumbai, India, (ii) need for relatively low-cost alternate technology to replace the solvent (MEK) extraction generator system in use in India since 1970s and (iii) minimize dependency on weekly import of fission-produced 99Mo raw material required for alumina column generator. Extensive investigations on process standardisation for zirconium molybdate gel (ZMG) led to a steady progress, achieved both in terms of process technology and final performance of 99mTc gel generators. The 99mTc final product purity from the Indian gel system was comparable to that obtained from the gold-standard alumina column generators. Based on the feasibility established for reliable small-scale production, as well as satisfactory clinical experience with a number of gel generators used in collaborating hospital radiopharmacies, full-fledged mechanised processing facilities for handling up to 150 g of ZMG were set up. The indigenous design and development included setting up of shielded plant facilities with pneumatic-driven as well as manual controls and special gadgets such as, microwave heating of the zirconium molybdate cake, dispenser for gel granules, loading of gel columns into pre-assembled generator housing etc. Formal review of the safety features was carried out by the regulatory body and stage-wise clearance for processing low and medium level 99Mo activity was granted. Starting from around 70 GBq 99Mo handling, the processing facilities have since been successfully operated at a level of 740 GBq 99Mo, twice a month. In all 18 batches of gel have been processed and 156 generators produced. The individual generator capacity was 15 to 30 GBq with an elution yield of nearly 75%. 129 generators were supplied to 11 user hospitals and the estimated number of clinical studies done is well over 5000. The salient aspects of the Indian experience have been reported in many a forum and shared with the IAEA through the on-going CRP. The detailed process know-how is available for technology transfer from BRIT, India. (author)
Primary Subject
Source
Argonne National Laboratory, Nuclear Engineering Division, RERTR Department, Argonne, IL (United States); Czech Technical University, Prague (Czech Republic); vp; Jul 2008; 12 p; RERTR-2007: 29. international meeting on reduced enrichment for research and test reactors; Prague (Czech Republic); 23-27 Sep 2007; Also available on-line: http://www.rertr.anl.gov/RERTR29/; Country of input: International Atomic Energy Agency (IAEA); 25 refs, 3 figs
Record Type
Report
Literature Type
Conference
Report Number
Country of publication
ALUMINIUM COMPOUNDS, ASIA, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BUILDINGS, CHALCOGENIDES, COLLOIDS, DAYS LIVING RADIOISOTOPES, DEVELOPING COUNTRIES, DISPERSIONS, ELEMENTS, EVEN-ODD NUCLEI, HEATING, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MATERIALS, MEDICAL ESTABLISHMENTS, METALS, MOLYBDENUM COMPOUNDS, MOLYBDENUM ISOTOPES, NUCLEI, ODD-EVEN NUCLEI, OXIDES, OXYGEN COMPOUNDS, RADIOISOTOPES, REACTORS, REFRACTORY METAL COMPOUNDS, RESEARCH AND TEST REACTORS, TECHNETIUM ISOTOPES, TRANSITION ELEMENT COMPOUNDS, TRANSITION ELEMENTS, YEARS LIVING RADIOISOTOPES
Reference NumberReference Number
Related RecordRelated Record
INIS VolumeINIS Volume
INIS IssueINIS Issue
External URLExternal URL