Filters
Results 1 - 1 of 1
Results 1 - 1 of 1.
Search took: 0.016 seconds
Acher, Peter; Rhode, Kawal; Morris, Stephen; Gaya, Andrew; Miquel, Marc; Popert, Rick; Tham, Ivan; Nichol, Janette; McLeish, Kate; Deehan, Charles; Dasgupta, Prokar; Beaney, Ronald; Keevil, Stephen F., E-mail: pete_acher@hotmail.com2008
AbstractAbstract
[en] Purpose: To present a method for the dosimetric analysis of permanent prostate brachytherapy implants using a combination of stereoscopic X-ray radiography and magnetic resonance (MR) imaging (XMR) in an XMR facility, and to compare the clinical results between XMR- and computed tomography (CT)-based dosimetry. Methods and Materials: Patients who had received nonstranded iodine-125 permanent prostate brachytherapy implants underwent XMR and CT imaging 4 weeks later. Four observers outlined the prostate gland on both sets of images. Dose-volume histograms (DVHs) were derived, and agreement was compared among the observers and between the modalities. Results: A total of 30 patients were evaluated. Inherent XMR registration based on prior calibration and optical tracking required a further automatic seed registration step that revealed a median root mean square registration error of 4.2 mm (range, 1.6-11.4). The observers agreed significantly more closely on prostate base and apex positions as well as outlining contours on the MR images than on those from CT. Coefficients of variation were significantly higher for observed prostate volumes, D90, and V100 parameters on CT-based dosimetry as opposed to XMR. The XMR-based dosimetry showed little agreement with that from CT for all observers, with D90 95% limits of agreement ranges of 65, 118, 79, and 73 Gy for Observers 1, 2, 3, and 4, respectively. Conclusions: The study results showed that XMR-based dosimetry offers an alternative to other imaging modalities and registration methods with the advantages of MR-based prostate delineation and confident three-dimensional reconstruction of the implant. The XMR-derived dose-volume histograms differ from the CT-derived values and demonstrate less interobserver variability
Primary Subject
Source
S0360-3016(08)00652-4; Available from http://dx.doi.org/10.1016/j.ijrobp.2008.03.065; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016;
; CODEN IOBPD3; v. 71(5); p. 1518-1525

Country of publication
BETA DECAY RADIOISOTOPES, BODY, DAYS LIVING RADIOISOTOPES, DIAGNOSTIC TECHNIQUES, ELECTRON CAPTURE RADIOISOTOPES, GLANDS, IMPLANTS, INDUSTRIAL RADIOGRAPHY, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, IODINE ISOTOPES, ISOTOPES, MALE GENITALS, MATERIALS TESTING, MEDICINE, NONDESTRUCTIVE TESTING, NUCLEAR MEDICINE, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIATION SOURCES, RADIOISOTOPES, RADIOLOGY, RADIOTHERAPY, TESTING, THERAPY, TOMOGRAPHY
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue