[en] The littlest Higgs (LH) model is the most economical one among various little Higgs models, which predicts the existence of the charged scalars Φ^±. In this paper, we study the production of the charged Higgs boson Φ^- with single top quark via the process gb → tΦ^- at the CERN Large Hadron Collider (LHC). The numerical results show that the production cross section is smaller than 0.2 pb in most of the parameters space, it is very difficult to observe the signatures of the charged scalars via the process pp → gb + X → tΦ^- + X at the LHC experiments. However, it can open a window to distinguish the top-pions in the TC2 model or charged Higgs in the MSSM from Φ^±