[en] Therapeutic, accidental and experimental radiation exposures decreased serum testosterone in males leading to various sexual problems. The present study was carried out to evaluate the radio-protective effect of royal jelly on rats exposed to radiation. Animals were divided into 4 groups; group 1:control group, group 2: rats received royal jelly (105mg/kg body wt/day) for successive 7 days, group 3: animals exposed to whole body gamma radiation (1Gy 7 times) day by day, group 4: animals received royal jelly 7 days pre-irradiation and during radiation exposure. However, plasma testosterone, plasma total proteins, albumin and globulin contents showed significant decrease as compared to the irradiated rats. Also, the administration of royal jelly showed decreased level of malondialdehyde and increased glutathione as compared to the irradiated group. Oral administration of the royal jelly to rats exerted a noticeable amelioration of the radiation-induced hormonal and biochemical changes according to the results of the present study