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AbstractAbstract
[en] The aim of this work is to estimate the uranium toxicity on the ovarian function and on the oocyte and more fundamentally to characterize the molecular ways regulating the oocyte degenerescence. At first, will be described the different exposure modes at uranium and the known toxic effects of this heavy metal on man and animal. The mechanisms regulating the follicle genesis and the oogenesis are then developed. At last, will be given the data available in literature and concerning the apoptosis ways intervening in the follicular atresia and in the oocyte degenerescence while referring to the known ways of the somatic cells. (O.M.)
Original Title
Etude de la degenerescence ovocytaire chez la souris: role des caspases et toxicite de l'uranium naturel
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Source
Apr 2008; 224 p; [460 refs.]; Also available from Bibliotheque Universitaire de medecine, 63 Rue Gabriel Peri, 94276 - Le Kremlin-Bicetre CEDEX (France); These Champ disciplinaire: aspects moleculaire et cellulaire de la biologie. Ecole doctorale de rattachement: signalisations, neurosciences, endocrinologie, reproduction
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Report
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Thesis/Dissertation
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