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[en] We consider the Friedberg-Lee symmetry for the quark sector and show that the symmetry closely relates to both quark masses and mixing angles. We also extend our scheme to the fourth generation quark model and find the relation |Vtb'|≅|Vt'b|≅mb/mb'<λ2 with λ≅0.22 for mb=4.2 GeV and mb'>199 GeV.