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AbstractAbstract
[en] Manganese (Mn) is not abundant in human brain tissue, but it is recognized as a neurotoxin. The symptoms of manganese intoxication are similar to Parkinson's disease (PD), but the link between environmental, occupational or dietary Mn exposure and PD in humans is not well established. X-ray Absorption Spectroscopy (XAS) and in particular X-ray fluorescence can provide precise information on the distribution, concentration and chemical form of metals. However the scattered radiation and fluorescence from the adjacent abundant element, iron (Fe), may interfere with and limit the ability to detect ultra-dilute Mn. A bent Laue analyzer based Mn fluorescence detection system has been designed and fabricated to improve elemental specificity in XAS imaging. This bent Laue analyzer of logarithmic spiral shape placed upstream of an energy discriminating detector should improve the energy resolution from hundreds of eV to several eV. The bent Laue detection system was validated by imaging Mn fluorescence from Mn foils, gelatin calibration samples and adult Drosophila at the Hard X-ray MicroAnalysis (HXMA) beamline at the Canadian Light Source (CLS). Optimization of the design parameters, fabrication procedures and preliminary experimental results are presented along with future plans.
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Source
SRI 2009: 10. international conference on radiation instrumentation; Melbourne (Australia); 27 Sep - 2 Oct 2009; (c) 2010 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Literature Type
Conference
Journal
Country of publication
AGE GROUPS, ANIMALS, ARTHROPODS, BODY, BREMSSTRAHLUNG, CENTRAL NERVOUS SYSTEM, DIPTERA, DISEASES, ELECTROMAGNETIC RADIATION, ELEMENTS, EMISSION, FLIES, FRUIT FLIES, INSECTS, INVERTEBRATES, IONIZING RADIATIONS, LUMINESCENCE, METALS, NERVOUS SYSTEM, OPTICAL PROPERTIES, ORGANS, PHOTON EMISSION, PHYSICAL PROPERTIES, RADIATION SOURCES, RADIATIONS, RESOLUTION, SPECTRA, SPECTROSCOPY, SURFACE PROPERTIES, TRANSITION ELEMENTS, X RADIATION
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