[en] Full text: A retrospective analysis of the case sheets of patients who had undergone high dose ¹³¹I ablation for differentiated thyroid carcinoma during the time period 2005 - 2007 were taken up for the analysis. 47.2% of the total patients were found to have measurable levels of thyroglobulin antibody which is much higher compared to the world literature. Presence of thyroglobulin antibody in the serum give rise to falsely low (high in IRMA) levels of thyroglobulin. Thyroglobulin antibody levels are being used as surrogate marker in such cases but the problem is it takes nearly 3 - 4 years for the antibody levels to come down though the patient may be disease free. Certain other methods of measurement of thyroglobulin and thyroglobulin antibody need to be developed which can separately measure thyroglobulin and thyroglobulin antibody levels