[en] We study the effect of squark-generation mixing on production and decays of squarks and gluinos at LHC in the Minimal Supersymmetric Standard Model (MSSM). We show that the mixing effects can be very large in a significant range of the squark-generation mixing parameters despite the very strong constraints on quark-flavour violation (QFV) from experimental data on B mesons. We find that under favourable conditions the QFV decay branching ratio B(g → c anti t(t anti c)χ₁⁰) can be as large as about 50%, which may lead to significant QFV signals at LHC. We also find that the squark generation mixing can result in a novel multiple-edge (3- or 4-edge) structure in the charm-top quark invariant mass distribution. Further we show that the two lightest up-type squarks u_1/2 can have very large branching ratios for the decays u_i →cχ₁⁰ and u_i →tχ₁⁰ simultaneously due to the mixing effect, resulting in QFV signals pp → c anti t(t anti c)+missing-E_T+X^' at a significant rate at LHC. These remarkable signatures could provide a powerful test of supersymmetric QFV at LHC and could have an important impact on the search for squarks and gluinos and the determination of the MSSM parameters at LHC. (orig.)