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Mendes, Jessica B.E.; Mainardes, Rubiana M.; Farago, Paulo V.; Michel, Milton D.; Zawadzki, Sonia F.
Associacao Brasileira de Polimeros (ABPol), Sao Carlos, SP (Brazil)2011
Associacao Brasileira de Polimeros (ABPol), Sao Carlos, SP (Brazil)2011
AbstractAbstract
[en] Resveratrol-loaded poly(ε-caprolactone) (PCL) microparticles were obtained by simple emulsion/solvent evaporation method. Three drug-loaded formulations were prepared with the aim of investigating the influence of composition on the encapsulation efficiency. Morphological and spectroscopic methods were performed for these materials. The microparticles revealed residual moisture close to 1.5% and encapsulation efficiency above 80%. Spherical shape and smooth surface were observed by SEM. No pores were either verified. Resveratrol-loaded microparticles showed an average particle size of around 50 μm. X-ray diffraction analysis demonstrated that the microencapsulation reduced the drug crystallinity. The FTIR results suggest that no chemical bond was formed between polymer and drug. (author)
Original Title
Microparticulas de poli(ε-caprolactona) contendo resveratrol: preparacao e caracterizacao
Source
2011; 6 p; 11. Brazilian congress on polymers; 11. Congresso brasileira de polimeros; Campos do Jordao, SP (Brazil); 16-20 Oct 2011
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