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AbstractAbstract
[en] After an introduction presenting the diagnosis and treatment of chronic lymphoid leukaemia, its molecular and genetic characteristics, and its cellular origin and clonal evolution, this research thesis describes the apoptosis (definition and characteristics, cancer and chemotherapy, apoptotic ways induced by gamma irradiation), the genotoxic stresses, the different repair mechanisms for different damages, and the DNA repair processes. It reports how human chronic lymphocytic leukaemia B cells can escape DNA damage-induced apoptosis through the non-homologous end-joining DNA repair pathway, and presents non-homologous end-joining DNA repair as a potent mutagenic process in human chronic lymphocytic leukaemia B cells
Original Title
Apoptose et stabilite de l'ADN dans la Leucemie Lymphoide Chronique-B: Implication du systeme de reparation des cassures double brin de l'ADN par recombinaison non homologue
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Secondary Subject
Source
23 Jun 2005; 260 p; [690 refs.]; Available from the INIS Liaison Officer for France, see the 'INIS contacts' section of the INIS website for current contact and E-mail addresses: http://www.iaea.org/INIS/contacts/. Also available from Bibliotheque interuniversitaire de pharmacie, 4 avenue de l'Observatoire, 75270 - Paris Cedex 06 (France); These pharmacie. Biologie moleculaire
Record Type
Report
Literature Type
Thesis/Dissertation
Report Number
Country of publication
BIOLOGICAL MATERIALS, BIOLOGICAL RECOVERY, BIOLOGICAL REPAIR, BLOOD, BLOOD CELLS, BODY FLUIDS, DISEASES, DNA DAMAGES, ELECTROMAGNETIC RADIATION, IMMUNE SYSTEM DISEASES, IONIZING RADIATIONS, MATERIALS, MEDICINE, MUTATIONS, NEOPLASMS, NUCLEAR MEDICINE, NUCLEIC ACIDS, ORGANIC COMPOUNDS, RADIATIONS, RADIOLOGY, REPAIR, THERAPY
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