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AbstractAbstract
[en] Per anhydro α-cyclodextrin exhibits in vivo and in vitro cation complexing properties. Furthermore, they have a high affinity for heavy toxic cations, while a quite negligible affinity for physiological cations (Na+, Ca2+, K+), that is to say a great selectivity. In order to apply these properties for biological decontamination, several alkyl derivatives were prepared by substitution at the 2 position and their cation complexing properties studied by 1H-NMR spectroscopy. Superficial tension measurements, 1H-NMR spectroscopy and gel formation showed that the properties of per anhydro cyclodextrin were tightly related with Log P, which also controlled their interactions with membranes. Membranes interactions are studied by surface plasmon resonance using BIAcore, 31P-NMR and 2H-NMR spectroscopies. (author)
[fr]
Les per anhydro α-cyclodextrines possedent in vivo et in vitro des proprietes complexantes vis a vis de cations. Plus particulierement ces molecules selectives possedent une forte affinite relative pour les cations toxiques par rapport aux cations physiologiques (Na+, Ca2+, K+). Dans le but d'utiliser ces molecules pour la decontamination en milieu biologique, plusieurs derives alkyles sont prepares par substitution en position C-2 et leurs proprietes complexantes sont etudiees par RMN-1H.Les proprietes de tension superficielle, la RMN-1H et la formation de gel en phase mixte des per anhydro cyclodextrines sont liees au logP, et suggerent fortement des interactions avec les membranes biologiques. Les effets sur les membranes sont etudies par la techique BIAcore, la RMN-31P et -2HOriginal Title
Synthese et etude des anhydro-cyclodextrines: application a la decontamination en milieu biologique
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28 Oct 2004; 200 p; 127 refs.; Available from the INIS Liaison Officer for France, see the 'INIS contacts' section of the INIS-NKM website for current contact and E-mail addresses: http://www.iaea.org/inis/contacts/; Chimie
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