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AbstractAbstract
[en] The efficiency and safety of the nuclear medicine practice depend, among others factors, of a quality control programme, mainly related to the use of the nuclide activity meters (activimeter). One of the most important sources of errors in the activimeter measurements is the thickness, size and volume of the vial that contains the radiopharmaceutical considering that a typical activimeter has its response dependent of the vial used. The objective of this work was to establish a quality control programme and the correction factors for the geometry of the vials used for distribution of radiopharmaceutical and activimeters calibration, considering that the Calibration Laboratory of Instruments (LCI) of the Instituto de Pesquisas Energeticas e Nucleares (IPEN) has a NPL-CRC Secondary Standard Radionuclide Calibrator System, manufactured for the Southern Scientific plc, compound by an ionization chamber well type and a current measurement system, with traceability to National Physical Laboratory (NPL) and calibrated with a P6 vial type with different dimensions of the one used for the IPEN. The radiopharmaceutical produced by IPEN 67Ga, '131I, 201Tl and 99mTc, had been tested using the two different vials. The results shown a maximum variation of 22% for 201Tl, and the minimum variation was 2.98% for 131I. The correction factors must be incorporated in the routine calibration of the activimeters. (author)
Original Title
Estudo e determinacao de fatores de influencia das dimensoes dos frascos de radiofarmacos utilizados no IPEN para calibracao de ativimetros
Primary Subject
Source
2010; 75 p; Diss. (M.Sc.)
Record Type
Miscellaneous
Literature Type
Thesis/Dissertation; Numerical Data
Report Number
Country of publication
BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BRAZILIAN ORGANIZATIONS, CONTROL, DATA, DAYS LIVING RADIOISOTOPES, DIMENSIONS, DRUGS, ELECTRON CAPTURE RADIOISOTOPES, GALLIUM ISOTOPES, HEAVY NUCLEI, HOURS LIVING RADIOISOTOPES, INFORMATION, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, IODINE ISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, MEASURING INSTRUMENTS, METERS, NATIONAL ORGANIZATIONS, NUCLEI, NUMERICAL DATA, ODD-EVEN NUCLEI, RADIATION DETECTORS, RADIOACTIVE MATERIALS, RADIOISOTOPES, TECHNETIUM ISOTOPES, THALLIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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