[en] ⁹⁰Y (T_/2 = 2,67 d; Eβmax = 2,28 MeV) is a radionuclide with efficacy established for various cancer therapies, labeling biomolecules and treating of radiosinovectomy. Due to its nuclear properties, is obtained through the decay of ⁹⁰Sr T_/2 = 28 y in the form of a generator. Several types of ⁹⁰Sr/⁹⁰Y generators were developed, and the most employed are the cation exchange resins, where Sr and Y are adsorbed and ⁹⁰Y is selectively eluted with acetate or EDTA. The disadvantage of this type of generator is the radiolysis, which degrades its use. The electrochemical generator is a proposed solution because there is no significant effect of radiation. In this concept, the difference between the electrochemical potentials of the elements Sr and Y is used to obtain a rapid separation of ⁹⁰Y from ⁹⁰Sr. The production of ⁹⁰Y via colloid formation is the simplest method for the separation, based on the colloid formation of Y in high alkaline pH, which can be filtered and separated from Sr, and subsequently dissolved in HCl. The objective of this work was the development of technologies for the preparation of ⁹⁰Sr/⁹⁰Y generators, and three technologies were developed: generators using cation resins columns, generators through colloid formation and electrochemical generators. Radionuclidic quality control of ⁹⁰Y was also evaluated by liquid scintillation, radionuclide identity, extraction paper chromatography (EPC) using complexing agents for ⁹⁰Y and by Optical Emission Spectrometry with Inductively Coupled Plasma (ICP-OES). The results showed that generators using cation resins have the best results related to the elution efficiency (∼83%), the reproducibility and radionuclidic purity. The electrochemical generator showed a potential for development, having the advantage of not suffering the effects of radiolysis of the pair ⁹⁰Sr/⁹⁰Y as the resin. A comparison and evaluation of the methods of the radionuclidic quality control showed that the EPC is very sensitive and allows for virtually instantaneous assessment of the quality of ⁹⁰Y generator. (author)