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[en] In order to explore probes for Aβ(1-40), Re(CO)3+-flavone derivative has been prepared and in vitro binding research showed Re(CO)3+-flavone derivative bond to Aβ(1-40) plaques with high affinity (0.65 nM) via fluorescence, then 99mTc(CO)3+-flavone derivative was prepared with high labeling yield of more than 99%. Biodistribution in normal mice demonstrated that uptake of 99mTc(CO)3+-flavone in brain was moderate (2 min,ID/g %: 0.42±0.13), and the clearance in brain was fast (2 min, ID/g %: 0.11±0.03), the results showed 99mTc(CO)3+-flavone should be a candidate as novel detector of Aβ(1-40) plaques. (authors)
Source
Chinese Nuclear Society, Beijing (China); 87 p; ISBN 978-7-5022-5040-9; 
; Nov 2010; p. 78-80; '09: academic annual meeting of China Nuclear Society; Beijing (China); 18-20 Nov 2009; 1 fig., 1 tab., 1 ref.
; Nov 2010; p. 78-80; '09: academic annual meeting of China Nuclear Society; Beijing (China); 18-20 Nov 2009; 1 fig., 1 tab., 1 ref.