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AbstractAbstract
[en] Quality control (QC) studies of three locally produced renal preparation of 99mTc-DTPA, 99mTc-GH and 99mTc-DMSA, as a part of the production activity before the Gulf war. The radioanalytical studies were performed using Gel Chromatography column Scanning (GCS) technique, although there are other alternative techniques. These kits tested for radiochemical purity and the labeling yields were found to be excellent. The biological studies included the following parameters; organ distribution (in mice, rats and rabbits), blood clearance in rabbits and plasma protein binding in rats at different time intervals. The poor renal concentration of three agents in mice was significant at two time intervals . The tissue distribution of DTPA, GH and DMSA kits, which were stored at 37 OC for 30 days in mice after intravenous injection of the radioactivity at 5, 30 and 60 minutes. The blood retention of the renal agents was considerably low compared to those in rats and rabbits at the respective time intervals. The blood clearance of 99m'Tc-DMSA was relatively slow and 99mTc-GH has rapid blood clearance identical with that of 99mtc-DTPA for the first 20 minutes but slower thereafter. The binding of DTPA, GH and DMSA with plasma protein was 5, and 95% at 1 hour respectively. Various amounts of tin (11) (as SnCl-2) were used in the kits with up to 10 times more of the usual dose for respective tin-complex and it was observed that there was no significant variation of the usual dose for respective tin-complex and its was observed that there was no significant variation of the organ distribution in mice. (Author)
Primary Subject
Source
Dec 2012; 15 p; 11. Arab Conference on the Peaceful use of Atomic Energy; Khartoum (Sudan); 23-27 Dec 2012; Also available from Sudan Atomic Energy Commission, Khartoum (SD); 18 refs.; 5 tabs.; 1 fig.
Record Type
Miscellaneous
Literature Type
Conference; Numerical Data
Report Number
Country of publication
ANIMALS, ARAB COUNTRIES, ASIA, BIOLOGICAL MATERIALS, BLOOD, BODY FLUIDS, CHLORIDES, CHLORINE COMPOUNDS, CLEARANCE, CONTROL, DATA, DEVELOPING COUNTRIES, DISTRIBUTION, EXCRETION, HALIDES, HALOGEN COMPOUNDS, INFORMATION, MAMMALS, MATERIALS, MIDDLE EAST, RODENTS, SEPARATION PROCESSES, TIN COMPOUNDS, TIN HALIDES, VERTEBRATES
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