[en] This study is part of a research programme conducted by IRSN on the safety of deep geological disposal of high level and intermediate long-lived radioactive wastes. It more especially concerns the geological medium considered as a full component of the multi-barrier concept proposed by Andra for a deep repository. Indeed, the Callovo-Oxfordian argillite of the Paris Basin, in the east of France, is being investigated by Andra as a potential host rock for this repository. Performance assessment of this natural barrier is based on the knowledge of its confinement properties and therefore on phenomena possibly involved in the mass transport of radionuclides. In this context, this work aimed at studying the distribution of tracers naturally present in pore waters obtained from boreholes having crossed Mesozoic sedimentary series involving impervious and compacted clay rocks in the East (Andra borehole, EST433) and south of France (IRSN boreholes). Radial diffusion and vapour exchange methods were used to calculate the concentrations and diffusion parameters of the studied tracers. In Tournemire formations, the different profiles describe a curved shapes attributed to a diffusive exchange between the argillite pore water and the surrounding aquifers. Concerning the Mesozoic formations crossed by EST433, the study of the different profiles confirms the diffusion as the dominant transport mechanism in the Callovo-Oxfordian formation, and permits identifying the transport processes in the whole studied column from the Oxfordian formations down to the Liassic one. This study also helps to identify the Liassic formations as a major source of salinity of the Dogger aquifer