[en] The purpose of this research thesis is to define the origin of numerous uranium anomalies in the external crystalline Alpine massifs, more precisely the massif of the Aiguilles Rouges and the massif of Belledonne. The primary cause of uranium mineralization in the first massif appears to have been the retrograde metamorphism events of the late-Hercynian age. In the second massif, the same conditions of uranium mineralization appear to have been realised, but with a much higher calcium activity in the fluids. After having explained the choice of the selected areas, the sampling and the chemical analysis performed, the author describes the geological and structural framework of Western Alps: geological history of the paleozoic platform, regional geology of the studied massifs. The next part reports the petrographic and geochemical study, the analysis of the mineral chemistry, of the alteration and the metamorphism. Then the author describes the geochemistry of uranium and thorium within the studied structures