[en] This thesis deals with the Baer-Nunziato two-phase flow model. The main objective of this work is to propose some techniques to cope with phase vanishing regimes which produce important instabilities in the model and its numerical simulations. Through analysis and simulation methods using Suliciu relaxation approximations, we prove that in these regimes, the solutions can be stabilised by introducing some extra dissipation of the total mixture entropy. In a first approach, called the Eulerian approach, the exact resolution of the relaxation Riemann problem provides an accurate entropy-satisfying numerical scheme, which turns out to be much more efficient in terms of CPU-cost than the classical and very simple Rusanov's scheme. Moreover, the scheme is proved to handle the vanishing phase regimes with great stability. The scheme, first developed in 1D, is then extended in 3D and implemented in an industrial code developed by EDF. The second approach, called the acoustic splitting approach, considers a separation of fast acoustic waves from slow material waves. The objective is to avoid the resonance due to the interaction between these two types of waves, and to allow an implicit treatment of the acoustics, while material waves are explicitly discretized. The resulting scheme is very simple and allows to deal simply with phase vanishing. The originality of this work is to use new dissipative closure laws for the interfacial velocity and pressure, in order to control the solutions of the Riemann problem associated with the acoustic step, in the phase vanishing regimes. (author)