[en] This document discusses the content of another one analysis issued by CIS Bio International and completing the safety re-examination file of its Saclay site. It first recalls the definition of such a safety re-examination (to make a review and assessment of the installation safety and radiation protection with respect to current safety and radiation protection regulation and practices, and a review and assessment of foreseen evolutions). It presents the installation of production of artificial radio-elements which was created at the beginning of the 1960's and which now only produces radio-pharmaceutical products which are used in nuclear medicine. It states the opinion of the IRSN on additional elements concerning the compliance examination, and the re-assessment of safety and radiation protection. It concludes that some works must be performed within the best delays in a basic nuclear installation, and that production increases suggested by CIS Bio International cannot be implemented under the current radiological zoning and staff dosimetry