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AbstractAbstract
[en] According to World Health Organization (WHO), cancer is a leading cause of death worldwide. Prostate cancer is the second most common cancer in men. A method of radiotherapy which has been extensively used is brachytherapy, where radioactive seeds are placed inside the area requiring treatment. Iodine-125 seeds can be placed loose or stranded in bioabsorbable polymers. Stranded seeds show some advantages, since they reduce the rate of seed migration, an event that could affect the dosimetry of the prostate and cause unnecessary damage to healthy tissues or organs. For Iodine-125 stranded seeds, polyglactin 910 (poly(lactic-co-glycolic acid)) (PLGA), with a coverage of polyglactin 370 (Vicryl ®) is used. It was purposed in this dissertation, the study and development of the synthesis methodology for PLGA via ring-opening polymerization, as well as its characterization, with the objective of using the synthesized material to manufacture a material similar to RAPID Strand®. The results obtained show that it was possible to determine the optimal reaction parameters (time and temperature) for PLGA in 80/20 (lactide/glycolide) ratio. Using a temperature of 110 ° C and reaction time of 24h, a yield of 86% was obtained, and increasing the reaction time to 72 hours, the yield was higher than 90%. The molecular mass values obtained from the samples are still very low compared to those obtained by other authors in the literature (about 20%). Failures in the sealing of vials, leaving them vulnerable to moisture and oxygen, or lack of an efficient stirring system might be possible explanations for these results. A suitable chemical reactor could solve the problem. Regarding polymer characterization, all techniques used not only confirmed the expected structure of the polymer, but also showed the highest proportion of lactide units compared to to glycolide units. (author)
Original Title
Desenvolvimento da metodologia para sintese do poli(acido latico-co-acido glicolico) para utilizacao na producao de fontes radioativas
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Secondary Subject
Source
2013; 73 p; Diss. (M.Sc.)
Record Type
Miscellaneous
Literature Type
Thesis/Dissertation
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BETA DECAY RADIOISOTOPES, BODY, CARBOXYLIC ACIDS, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, GLANDS, HYDROXY ACIDS, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, IODINE ISOTOPES, ISOTOPES, MALE GENITALS, MEDICINE, MONOCARBOXYLIC ACIDS, NUCLEAR MEDICINE, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANS, RADIOISOTOPES, RADIOLOGY, RADIOTHERAPY, THERAPY
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