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Li Yan; Zhang Qiuyan; Guo Yunxing; Jia Hongmei; Liu Boli; Winnie Deuther-Conrad; Peter Brust; Joerg Steinbach; Bernhard Wuensch
Proceedings of 26. annual academic conference of China Chemical Society--modern nuclear chemistry and radiochemistry2008
Proceedings of 26. annual academic conference of China Chemical Society--modern nuclear chemistry and radiochemistry2008
AbstractAbstract
[en] The radioiodinated 1'-(4-iodo-benzyl) spiro [isobenzofuran-1(3H), 4'-piperidine] (["1"2"5I] Spiro-I) and its stable reference compound were synthesized. Competition binding assays in vitro showed that Spiro-I displayed high affinity and selectivity (σ_1: K_i = 2.75 nM; σ_2: K_i = 340 nM) for σ_1 receptor. Biodistribution and inhibition studies demonstrated that ["1"2"5I] Spiro-I bounded selectively to σ_1 receptor in vivo. Therefore, ["1"2"5I] Spiro-I may be potential σ_1 receptor imaging agent. (authors)
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China Chemical Society, Beijing (China); 126 p; Aug 2008; p. 36; 26. annual academic conference of China Chemical Society--modern nuclear chemistry and radiochemistry; Tianjin (China); 13-16 Jul 2008; Available from China Nuclear Information Centre (China Institute of Nuclear Information & Economics), inisservice_cn@163.com; 3 refs.
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Miscellaneous
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Conference
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BETA DECAY RADIOISOTOPES, DAYS LIVING RADIOISOTOPES, DISEASES, DRUGS, ELECTRON CAPTURE RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, IODINE ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, MEMBRANE PROTEINS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, PROTEINS, RADIOACTIVE MATERIALS, RADIOASSAY, RADIOISOTOPES, TRACER TECHNIQUES
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