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Mueller, W.F.; Patil, A.; Russ, W.R.; Newman, J.; Torgue, J.
Institute of Electrical and Electronics Engineers - IEEE, 3 Park Avenue, 17th Floor, New York, N.Y. 10016-5997 (United States)2015
Institute of Electrical and Electronics Engineers - IEEE, 3 Park Avenue, 17th Floor, New York, N.Y. 10016-5997 (United States)2015
AbstractAbstract
[en] AREVA Med, an AREVA group subsidiary, is developing innovative cancer-fighting therapies involving the use of "2"1"2Pb for alpha radioimmunotherapy. Canberra Industries, the nuclear measurement subsidiary of AREVA, has been working with AREVA Med to develop a prototype measurement system to assay syringes containing a "2"1"2Pb solution following production by an elution system. The relative fraction of emitted radiation from the source associated directly with the "2"1"2Pb remains dynamic for approximately 6 hours after the parent is chemically purified. A significant challenge for this measurement application is that the short half-life of the parent nuclide requires assay prior to reaching equilibrium with progeny nuclides. A gross counting detector was developed to minimize system costs and meet the large dynamic range of source activities. Prior to equilibrium, a gross counting system must include the period since the "2"1"2Pb was pure to calculate the count rate attributable to the parent rather than the progeny. The dynamic state is determined by solving the set of differential equations, or Bateman equations, describing the source decay behavior while also applying the component measurement efficiencies for each nuclide. The efficiencies were initially estimated using mathematical modeling (MCNP) but were then benchmarked with source measurements. The goal accuracy of the system was required to be within 5%. Independent measurements of the source using a high resolution spectroscopic detector have shown good agreement with the prototype system results. The prototype design was driven by cost, compactness and simplicity. The detector development costs were minimized by using existing electronics and firmware with a Geiger-Mueller tube derived from Canberra's EcoGamma environmental monitoring product. The acquisition electronics, communications and interface were controlled using Python with the EcoGamma software development kit on a Raspberry Pi Linux computer mounted inside a standard project box. The results of initial calibration measurements are presented. (authors)
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2015; 7 p; ANIMMA 2015: 4. International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications; Lisboa (Portugal); 20-24 Apr 2015; Available from the INIS Liaison Officer for France, see the 'INIS contacts' section of the INIS website for current contact and E-mail addresses: http://www.iaea.org/inis/Contacts/; Country of input: France; 5 Refs.
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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CHARGED PARTICLES, COMPUTER CODES, DISEASES, EVEN-EVEN NUCLEI, HEAVY NUCLEI, HOURS LIVING RADIOISOTOPES, IMMUNOTHERAPY, IONIZING RADIATIONS, ISOTOPES, LEAD ISOTOPES, MEDICINE, NUCLEAR MEDICINE, NUCLEI, RADIATIONS, RADIOISOTOPES, RADIOLOGY, RADIOTHERAPY, THERAPY
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