[en] Using γ-H2AX foci assay, we found that IL-6 pretreatment facilitates the repair of DNA damage. Furthermore, we observed an increased expression of anti-apoptotic proteins from Bcl2 family (Bcl2, Bcl-xl) along with reduced apoptosis, and increased expression of survivin, cyclin D. In addition, we observed an increased NF-kB activation in IL-6 treated cells. As the metabolic switch towards glycolysis is also an important mechanism to cause radioresistance in cells. In our study we found a significant increase in glycolysis after IL-6 treatment. And this IL-6 mediated protection was abolished after using a potent glycolytic inhibitor (2-DG). In conclusion, our study suggests that IL-6 protects the cells from radiation induced cell death by inducing antioxidant defense system and pro-survival signaling