Filters
Results 1 - 1 of 1
Results 1 - 1 of 1.
Search took: 0.027 seconds
Loo, Yihua; Hauser, Charlotte A E, E-mail: charlotte.hauser@kaust.edu.sa2016
AbstractAbstract
[en] Three-dimensional (3D) bioprinting is a disruptive technology for creating organotypic constructs for high-throughput screening and regenerative medicine. One major challenge is the lack of suitable bioinks. Short synthetic self-assembling peptides are ideal candidates. Several classes of peptides self-assemble into nanofibrous hydrogels resembling the native extracellular matrix. This is a conducive microenvironment for maintaining cell survival and physiological function. Many peptides also demonstrate stimuli-responsive gelation and tuneable mechanical properties, which facilitates extrusion before dispensing and maintains the shape fidelity of the printed construct in aqueous media. The inherent biocompatibility and biodegradability bodes well for in vivo applications as implantable tissues and drug delivery matrices, while their short length and ease of functionalization facilitates synthesis and customization. By applying self-assembling peptide inks to bioprinting, the dynamic complexity of biological tissue can be recreated, thereby advancing current biomedical applications of peptide hydrogel scaffolds. (paper)
Primary Subject
Source
Available from http://dx.doi.org/10.1088/1748-6041/11/1/014103; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Biomedical Materials (Bristol. Online); ISSN 1748-605X;
; v. 11(1); [7 p.]

Country of publication
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue