[en] The deep geological repository concept for the long-term management of used nuclear fuel involves the containment and isolation of used nuclear fuel in a suitable geological formation. A key objective of the Canadian Nuclear Waste Management Organization (NWMO) geoscience technical research program is to advance the understanding of geosphere stability and its resilience to perturbations over time frames of relevance to a deep geological repository. Glaciation has been identified as the most probable and intense perturbation relevant to a deep geological repository associated with long-term climate change in northern latitudes. Given that the North American continent has been re-glaciated nine times over the past million years, it is strongly expected that a deep geological repository within a suitable crystalline or sedimentary rock formation in Canada will be subject to glaciation events associated with long-term climate change. As such, NWMO's geoscience research program has placed particular emphasis on investigations of the response of the geosphere to glaciations. As surface conditions change from present day conditions to periglacial, followed by ice-sheet cover of variable thickness and rapid glacial retreat, transient geochemical, hydraulic, mechanical and temperature conditions will be simultaneously imposed on groundwater systems. NWMO research activities related to glaciation events and their impacts on groundwater system evolution are being undertaken using a multi-disciplinary approach aimed at collecting multiple lines of evidence. These investigations include assessment of the: Impact of an ice sheet on groundwater composition at repository depth using the Greenland Ice Sheet as an analogue to future glaciations in North America; Expected physical and temporal surface boundary conditions related to potential future glaciation events by estimating the magnitude and time rate of change of ice sheet thickness, ground surface temperature and permafrost occurrence, amongst other attributes; Evolution of deep groundwater systems and impacts of Coupled Thermo-Hydro-Mechanical effects imposed by glacial cycles; Impacts of climate change on redox stability using both numerical simulations and paleohydrogeological investigations; and Potential for seismicity and faulting induced by glacial rebound. This paper presents an overview of studies underway as part of the Greenland Analogue Project (GAP) to evaluate the impact of an ice sheet on groundwater chemistry at repository depth using the Greenland Ice Sheet as an analogue to future glaciations in North America. The study of the Greenland Ice Sheet will allow us to increase our understanding of hydrological, hydrogeological and geochemical processes during glacial conditions. (author)