[en] Highlights: • Gas emissions, fuel properties and performance engine modeling. • Optimization of new modified fuel prepared from n-Butanol and Nano particles. • Model accuracy analysis. - Abstract: This essay scrutinizes an experimental study conducted to appraise the influence of using n-Butanol with diesel fuel in 5% and 10% (volume) n-Butanol, 1% nitro methane (NM), injection timing and two Nano-particles (alumina and a type of silica powder) on the engine performance (brake specific fuel consumption and engine power), fuel properties (Cetane number and flash point) and exhaust emissions (soot, NO_x and CO) of an engine with 4-cylinder (with a system of common rail fuel injection), intercooling, cooled exhaust gas recirculation (EGR), and turbocharged. The tests are conducted by varying the engine load (25 and 75 nm) and changing engine speed (1500 and 2200 rpm). Normal Butanol presents better brake specific fuel consumption (BSFC) but this blend doesn’t reflect better engine power. All the percentages of n-Butanol in the fuel make Cetane number decrease but adding 1% of nitro methane makes Cetane number increase. For all the n-Butanol, the percentage flash makes the fuel decrease in comparison to pure diesel fuel. The current experimental study demonstrates that adding the n-Butanol and nitro methane to diesel fuel direct into diminishing soot emission. In contrast, this blend raises NO_x and CO emissions. Furthermore, this research indicates that the increase of engine speed dwindle air pollutants and enhances BSFC. It also remarks that power gets increased at low engine speed. However, power gets reducedat high speed. This article represents that the increasing of engine load leads to increasing all of air pollutant, increasing of power and decreasing of brake specific fuel consumption. Both the Cetane number and flash point are independent from engine speed and engine load. The present paper shows that the effect of silica with high percentage of n-Butanol and high injection timing are better than other additives soot emissions which are getting decreased. Moreover, these additives along with low injection timing are more suitable for increasing the brake specific fuel consumption.