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Experimental validation of gallium production and isotope-dependent positron range correction in PET
Fraile, L.M.; Herraiz, J.L.; Udías, J.M.; Cal-González, J.; Corzo, P.M.G.; España, S.; Herranz, E.; Pérez-Liva, M.; Picado, E.; Vicente, E.; Muñoz-Martín, A.; Vaquero, J.J., E-mail: lmfraile@ucm.es2016
AbstractAbstract
[en] Positron range (PR) is one of the important factors that limit the spatial resolution of positron emission tomography (PET) preclinical images. Its blurring effect can be corrected to a large extent if the appropriate method is used during the image reconstruction. Nevertheless, this correction requires an accurate modelling of the PR for the particular radionuclide and materials in the sample under study. In this work we investigate PET imaging with "6"8Ga and "6"6Ga radioisotopes, which have a large PR and are being used in many preclinical and clinical PET studies. We produced a "6"8Ga and "6"6Ga phantom on a natural zinc target through (p,n) reactions using the 9-MeV proton beam delivered by the 5-MV CMAM tandetron accelerator. The phantom was imaged in an ARGUS small animal PET/CT scanner and reconstructed with a fully 3D iterative algorithm, with and without PR corrections. The reconstructed images at different time frames show significant improvement in spatial resolution when the appropriate PR is applied for each frame, by taking into account the relative amount of each isotope in the sample. With these results we validate our previously proposed PR correction method for isotopes with large PR. Additionally, we explore the feasibility of PET imaging with "6"8Ga and "6"6Ga radioisotopes in proton therapy.
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S0168-9002(16)00016-4; Available from http://dx.doi.org/10.1016/j.nima.2016.01.013; Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Nuclear Instruments and Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment; ISSN 0168-9002;
; CODEN NIMAER; v. 814; p. 110-116

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BEAMS, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, CALCULATION METHODS, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, ELECTRON CAPTURE RADIOISOTOPES, EMISSION COMPUTED TOMOGRAPHY, ENERGY RANGE, GALLIUM ISOTOPES, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOTOPES, MEDICINE, MEV RANGE, MOCKUP, NUCLEAR MEDICINE, NUCLEI, NUCLEON BEAMS, ODD-ODD NUCLEI, PARTICLE BEAMS, PROCESSING, RADIOISOTOPES, RADIOLOGY, RESOLUTION, STRUCTURAL MODELS, TESTING, THERAPY, TOMOGRAPHY
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