[en] The charmless B_c→PP,PV decays (where P and V denote the light pseudoscalar and vector mesons, resp.) can occur only via the weak annihilation diagrams within the Standard Model. In this paper, we study these kinds of decays in the framework of QCD factorization, by adopting two different schemes: scheme I is similar to the method usually adopted in the QCD factorization approach, while scheme II is based on the infrared behavior of gluon propagator and running coupling. For comparison, in our calculation, we adopt three kinds of wave functions for B_c meson. The branching ratios based on the two schemes are given. It is found that (a) the predicted branching ratios in scheme I are, however, quite small and almost impossible to be measured at the LHCb experiment and (b) in scheme II, by assigning a dynamical gluon mass to the gluon propagator, we can avoid enhancements of the contribution from soft endpoint region. The strength of annihilation contributions predicted in scheme II is enhanced compared to that obtained in scheme I.