[en] Light-front Hamiltonian field theory has advanced to the stage of becoming a viable non-perturbative method for solving forefront problems in strong interaction physics. Physics drivers include hadron mass spectroscopy, generalized parton distribution functions, spin structures of the hadrons, inelastic structure functions, hadronization, particle production by strong external time-dependent fields in relativistic heavy ion collisions, and many more. We review selected recent results and future prospects with basis light-front quantization that include fermion-antifermion bound states in QCD, fermion motion in a strong time-dependent external field and a novel non-perturbative renormalization scheme. (author)